Related Products of 25597-16-4,Some common heterocyclic compound, 25597-16-4, name is Ethyl 4,4,4-trifluorocrotonate, molecular formula is C6H7F3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0714] To a solution of 6.0 g (24 mmol) OF 2-HYDROXY-5-IODOBENZALDEHYDE and 5 mL (33.3 mmol) of ethyl 4,4, 4-trifluorocronate in 20 mL of dry DMF at 60 C was added potassium carbonate in one portion. The mixture was stirred at 60 C overnight. After cooling to room temperature, the solid was filtered and washed with EtOAc. The combined filtrates were diluted by addition with 300 mL EtOAc and washed with brine. The organic phase was dried over anhydrous magnesium sulfate and evaporated to afford an oil, which was further purified silica gel chromatography with EtOAc/hexane (1: 9). Concentration of the desired fractions afforded 4.7 g (49%) of a light yellow solid : H NMR (CDCL3/300 MHz) 7.65-7. 55 (m, 3H), 6.78 (d, J=8. 4Hz, 1H), 5.72 (q, J=6. 6 Hz, 1H), 4.34 (m, 2H), 1.37 (t, J=6. 9 Hz, 3H). MS (ES+) 398.9 (M+H, 100).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4,4,4-trifluorocrotonate, its application will become more common.
Reference:
Patent; PHARMACIA CORPORATION; WO2004/87686; (2004); A2;; ; Patent; PHARMACIA CORPORATION; WO2004/87687; (2004); A1;,
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