Reference of 103-26-4, A common heterocyclic compound, 103-26-4, name is Methyl cinnamate, molecular formula is C10H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
6-methyl-4-phenyl-chromen-2-one (I ; X+Z=0 ; W = CO) 2-Bromo-4-methylphenol (2.4 ml ; 19.7 MMOL), ET4NCI (2.2 g; 13.3 MOI), CY2 (Me) N (4.2 ml ; 19.7 MMOL) and Pd (OAC) 2 (59 mg; 0.26 MMOL) were added under nitrogen at room temperature to a solution of methyl cinnamate (2.1 g; 13.1 MMOL) in DIMETHYLACETAMIDE (40 ML). The reaction mixture was stirred at 959C for 48 h, then cooled and filtered on celite. The solution was diluted with Et20 and washed 3 times with H20. The organic phase was dried over NA2SO4 and the solvent was evaporated under vacuum. GC-MS showed a conversion of 94%. The raw reaction product was purified by flash chromatography. (SIO2, n-hexane: Et20 7: 3) and the fractions collected were crystallized from ET20/N-HEXANE to give pale yellow crystals (2.4 g; 77% yield).
The synthetic route of 103-26-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CONSIGLIO NAZIONALE DELLE RICERCHE; PICCOLO, Oreste; WO2005/5356; (2005); A2;,
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