Electric Literature of 52787-14-1,Some common heterocyclic compound, 52787-14-1, name is Methyl 4-(2-methoxy-2-oxoethyl)benzoate, molecular formula is C11H12O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A 50-mE round-bottom flask was charged with methyl 4-(2-methoxy-2-oxoethyl) benzoate (1 g, 4.80 mmol), (dimethoxymethyl)dimethylamine (571 mg, 4.79 mmol) and N,N-dimethylformamide (15 mE). The resulting solution was stirred for 4 h at 60 C. Afier cooling to 23 C., the reaction was quenched with water (30 mE) and the product was extracted with ethyl acetate (3×30 mE). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified by colunm chromatography eluting with ethyl acetate/petroleum ether (1:1 v/v) to afford methyl 4-(1 -(dimethylamino)-3- methoxy-3-oxoprop- 1 -en-2-yl)benzoate as a yellow solid (800 mg, 63%). ECMS: (ESI) mlz 264 [M+H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-(2-methoxy-2-oxoethyl)benzoate, its application will become more common.
Reference:
Patent; Forma Therapeutics, Inc.; Ioannidis, Stephanos; Talbot, Adam Charles; Follows, Bruce; Buckmelter, Alexandre Joseph; Wang, Minghua; Campbell, Ann-Marie; Schmidt, Darby Rye; Guerin, David Joseph; Caravella, Justin A.; Diebold, R. Bruce; Ericsson, Anna; Lancia, JR., David; (225 pag.)US2016/185785; (2016); A1;,
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