Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 685-88-1, name is Diethyl fluoromalonate, A new synthetic method of this compound is introduced below., SDS of cas: 685-88-1
General procedure: All flasks and stirrer bars were flame dried before use. Tothe N-oxide (0.2 mmol, 1.0 equiv.), dissolved in 2 cm3dichloromethane was added Tf2O (0.3 mmol, 1.5 equiv.) at0 C. In another flask, a suspension of NaH (0.7 mmol, 3.5equiv.) in 1 cm3 tetrahydrofuran was cooled to 0 C andthe malonate (0.7 mmol, 3.5 equiv.) was added. After15 min, the malonate solution was added to the activatedN-oxide solution and the mixture was stirred at roomtemperature for 1 h. The reaction was quenched withNH4Cl solution and the aqueous phase was extracted withdichloromethane. The combined organic layers werewashed with brine before being dried over MgSO4. Thesolvents were removed under reduced pressure and thecrude product was purified by column chromatography.
The synthetic route of 685-88-1 has been constantly updated, and we look forward to future research findings.
Reference:
Erratum; Lemmerer, Miran; Teskey, Christopher J.; Kaiser, Daniel; Maulide, Nuno; Monatshefte fur Chemie; vol. 149; 4; (2018); p. 721 – 722;,
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