Brief introduction of 57486-68-7

Electric Literature of 57486-68-7,Some common heterocyclic compound, 57486-68-7, name is Methyl 2-chlorophenylacetate, molecular formula is C9H9ClO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example Al4; (1) To a solution of methyl 2-chlorophenylacetate (10 g) in dimethylformamide (150 mL) was added N, N- dimethylformamide dimethylacetal (14.4 mL) , and the mixture was stirred at 85C overnight. After cooling to room temperature, to the reaction mixture was added ethyl acetate and water. After stirring, the organic layer was separated, dried over sodium sulfate and filtered, and the filtrate was concentrated in vacuo. The residue was diluted with acetic acid (18 mL) , and -thereto were added 3- amino-4-ethoxycarbonyl-lH-pyrazole (8.4 g) and piperidine(1.1 mL) . The mixture was stirred at 800C for 3.5 hours.After cooling to room temperature, to the reaction mixture were added ethyl acetate and water. The mixture was stirred and filtered, and the resultant -? precipitates were dried to give 3- [2- (2-chlorophenyl) -2-methoxycarbonyl- vinylamino] -4-ethoxycarbonyl-lH-pyrazole (11.8 g, yield: 62%) as a powder. MS(APCI)m/z; 350/352 [M+H]+; Reference Example A14B; To a solution of methyl 2-chlorophenylacetate (25 g) in dimethylformamide (400 itiL) was added N, N- dimethylformamide diralphaethylacetal (36 itiL) , and the mixture was stirred at 90 C overnight. After cooling to room temperature, to the reaction mixture were added ethyl acetate and water. After stirring, the organic layer was separated, dried over magnesium sulfate and filtered, and the filtrate was concentrated in vacuo. The residue was diluted with acetic acid (60 itiL) , and thereto was added 3- amino~4-ethoxycarbonyl-5-methyl-lH-pyrazole (19.7 g) . The mixture was stirred at 1200C overnight. After cooling the reaction mixture to room temperature, the precipitates were collected by filtration, washed with ethyl acetate/diisopropylether (1/1) and dried to give 6- (2- chlorophenyl) -3-ethoxycarbonyl-2-methyl-7-oxo-4 , 7- dihydropyrazolo [1, 5-a] pyrimidine (26.0 g) as a powder. MS(APCI)m/z; 332/334 [M+H]+

The synthetic route of 57486-68-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; WO2008/4698; (2008); A2;,
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