Synthetic Route of 36692-49-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36692-49-6 as follows.
Example 96; (2Z,5Z)-2-[(2,6-dichlorophenyl)imino]-5-{[2-(1-methylethyl)-1H-benzimidazol-6-yl ]methylidene}-1,3-thiazolidin-4-one; (a) methyl 2- (1-methylethyl)-lHbenzimidazole-6-carboxylate; A solution of isobutyraldehyde (0.22 mL, 2.41 mmol) and 40 % aq. sodium hydrogen sulfite (2.6 mL) was stirred at room temperature for 1 h. To this mixture is added a solution of methyl 3,4-diaminobenzoate (0.400 g, 2.41 mmol) in ethanol (2 mL). The resulting solution is heated to reflux overnight. The mixture was diluted in water and the resulting precipitate was collected by filtration to obtain 0.524 g of the desired product in >99 % yield. The crude was used without further purification. [MS (ES+) m/e 219 M+H] +. 1H NMR (400 MHz, CHLOROFORM-d) 8 ppm 8.30 (d, =7=1. 0 Hz, 1 H) 7.93 (dd, J=8. 6,1. 5 Hz, 1 H) 7.54 (d, 8. 6 Hz, 1 H) 3.90 (s, 3 H) 3.30-3. 41 (m, 1 H) 1. 48 (d, 7. 1 Hz, 6 H).
According to the analysis of related databases, 36692-49-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/82901; (2005); A1;,
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