In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34837-84-8 as follows. Recommanded Product: Methyl 2-(4-fluorophenyl)acetate
Step El. To a solution of diisopropylamine (4.24 mL, 29.7 mmol) in THF (100 mL) at -5 ¡ãC under nitrogen was added a solution of 2.5 M n-butyllithium in hexanes (11.9 mL, 29.7 mmol) dropwise via syringe. After stirring for 15 min, methyl 2-(4-fluorophenyl)acetate (commercially available, 5.0 g, 29.7 mmol) was added. The mixture was stirred at -5 ¡ãC for 30 min and then treated with iodomethane (1.86 mL, 29.7 mmol). The reaction mixture was allowed to gradually warm to rt. After 4 h at rt, the reaction mixture was poured into a solution of aqueous ammonium chloride. The resulting mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried (magnesium sulfate), filtered, and concentrated in vacuo. The crude product was purified using silica gel column chromatograpy (20: 1 hexane/ethyl acetate) to afford methyl 2-(4- fluorophenyl)propanoate (2.32 g, 43 percent yield) as a clear liquid. 1H NMR (500 MHz, chloroform-d) delta 7.33 – 7.25 (m, 2H), 7.09 – 6.98 (m, 2H), 3.73 (q, J=7.2 Hz, IH), 3.69 (s, 3H), 1.51 (d, J=7.2 Hz, 3H).
According to the analysis of related databases, 34837-84-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MARCIN, Lawrence R.; HIGGINS, Mendi A.; BRONSON, Joanne J.; ZUSI, F. Christopher; MACOR, John E.; DING, Min; WO2015/42243; (2015); A1;,
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