Related Products of 24807-40-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 24807-40-7 name is Methyl 3-(4-(benzyloxy)phenyl)propanoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2 N Sodium hydroxide aqueous solution (3.5 mL) and water (10 mL) were added to a tetrahydrofuran-methanol solution (20 mL-10 mL) of the compound obtained in (1) (1.60 g), and stirred for 1 hour at 60C. The reaction solution was made acidic with 1 N hydrochloric acid, and then extracted with diethyl ether. The extract was washed with saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was recrystallized from diethyl ether-hexane to obtain 3-[4-(benzyloxy)phenyl] propionic acid (1.27 g) as colorless crystals. 1H-NMR (300MHz, CDCl3); delta 2.65 (2H, t, J=7.8Hz), 2.91 (2H, t, J=7.8Hz), 5.04 (2H, s), 6.91 (2H, d, J=8.7Hz), 7.13 (2H, d, J=8.7Hz), 7.29-7.45 (5H., m)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-(4-(benzyloxy)phenyl)propanoate, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1849465; (2007); A1;,
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