Application of 99548-54-6, A common heterocyclic compound, 99548-54-6, name is Methyl 3-bromo-2-methylbenzoate, molecular formula is C9H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound I-1B (4.56 g, 20 mmol) was dissolved in anhydrous THF (100 mL).After cooling to 0 C, LAH (0.8 g, 20 mmol) was added in portions to maintain the internal temperature of the reaction solution less than 5 C. After the addition, the temperature was slowly raised to room temperature for 2 hours.TLC showed that after the reaction was over, it was re-cooled to 0 C, 0.8 ml of water was added dropwise, 0.8 ml of 15% NaOH and 2.4 ml of water were added, and after stirring, the mixture was stirred for 1 hour and filtered.The obtained filtrate was dried to give Compound I-1C (3.7 g, yellow solid).Yield: 92.4%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Guangzhou Dankang Pharmaceutical Biological Co., Ltd.; Xu Yong; Huang Lu; Lin Dang; Hu Hai; (29 pag.)CN110092740; (2019); A;,
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