Application of 34837-84-8,Some common heterocyclic compound, 34837-84-8, name is Methyl 2-(4-fluorophenyl)acetate, molecular formula is C9H9FO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Stir at 0 C,To sodium hydride (60% in mineral oil, 2.62 g, 65.5 mmol)Anhydrous tetrahydrofuran (60 mL)Methyl 2-(4-fluorophenyl)acetate (IV-1, 5 g, 29.73 mmol) was added dropwise to the suspension.The resulting mixture was stirred at 0 C for 0.5 hours.Then slowly add methyl iodide (12.7 g, 89.4 mmol).After the addition was completed, the reaction mixture was stirred at 50 C for 5 hours.Quenched with ice water (100 mL),Extracted with ethyl acetate (40 mL ¡Á 3).Combine the organic phase,Dried over anhydrous sodium sulfate,Filter and concentrate in vacuo,Made yellow oilMethyl 2-(4-fluorophenyl)-2-methylpropanoate(IV-2, 5.7 g, yield: 98%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-(4-fluorophenyl)acetate, its application will become more common.
Reference:
Patent; Guangzhou Yingsheng Biological Technology Co., Ltd.; Li Jingrong; Li Anhu; (57 pag.)CN110092804; (2019); A;,
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