Synthetic Route of 35180-01-9,Some common heterocyclic compound, 35180-01-9, name is Chloromethyl isopropyl carbonate, molecular formula is C5H9ClO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In 1000 ml reaction flask by adding 400 ml acetonitrile, 50mlNMP and 40g tynofovir a water composition, stirring is opened, to control the temperature to 20 C dropping under 67g triethylamine, drops to continue dropping 100g chloro methyl isopropyl carbonate, the reaction system after the dipping temperature is increased to 50 C insulation reaction 8 hours, the detection reaction monoester less than 10%, in the reaction liquid 40 C the following concentrate under reduced pressure until there is no liquid can flow out, in the concentrated residual liquid by adding 500 ml ethyl acetate, 200ml6% of sodium bicarbonate solution, stir layered after extraction, the organic phase continue to use 200 ml purified water washing two times, the resulting organic phase after drying by anhydrous sodium sulfate concentrated under reduced pressure to dry, the resulting concentrated residual liquid directly used for the next reaction.
The synthetic route of 35180-01-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Suzhou Homesun Pharmaceutical Co., Ltd.; Fan, Chao; (7 pag.)CN105418684; (2016); A;,
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