Reference of 61367-07-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61367-07-5 name is Methyl trans-4-aminocyclohexanecarboxylate hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 1.5 g (7.745 mmol) of methyl frans-4-aminocyclabexanecarboxyiate hydrochloride, 4 mL (46.5 mmol) of 2-fiuoropyridine and 1.35 mL (7.75 mmol) of DIPEA was stirred at 125 C in a pressure-resistant glass reactor for 20 hours, then cooled to room temperature. The reaction mixture was diluted with 20 mL of ethyl acetate, washed with 2×30 mL of water and saturated NaCI solution, the organic phase was dried over anhydrous Na2S04, filtered and concentrated to yield 325 mg (18%) of the title compound. MS (ESI) m/z 235.1 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl trans-4-aminocyclohexanecarboxylate hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; RICHTER GEDEON NYRT.; BATA, Imre; SZELECZKY, Zsolt; SZONDINE KORDAS, Krisztina; SZANTO, Gabor; (191 pag.)WO2019/116325; (2019); A1;,
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