Electric Literature of 13195-64-7,Some common heterocyclic compound, 13195-64-7, name is Diisopropyl malonate, molecular formula is C9H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In 820mmol of sodium hydride as catalyst, 200mmol 440mmol diisopropyl malonate with propargyl bromide was added to 250mLof anhydrous acetonitrile in an ice-water bath with stirring for 8 hours, the product was washed with water, added with ethyl acetate, spin dried under reduced pressure, ethyl acetate: petroleumether = 1: 100 (volume ratio) as eluent column chromatography, the desired product was collected and concentrated to give a white solid product, i.e. compound a-1;
The synthetic route of 13195-64-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anhui Normal University; Lu, Shuang; Hu, Yimin; (14 pag.)CN105777679; (2016); A;,
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