Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 126541-82-0, name is Methyl 3-amino-4-(trifluoromethyl)benzoate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 3-amino-4-(trifluoromethyl)benzoate
Step C: Methyl 3-cyano-4-(trifluoromethyl)benzoateTo a mixture of methyl 3-amino-4-(trifluoromethyl)benzoate (3.2 g, 15 mmol) and aqueous HC1 solution (12 M, 3.5 mL) in water (20 mL) was added dropwise a solution of NaN02 (1.2 g, 17 mmol) in water (7.0 mL) at 5 C. The resulting mixture was stirred for 30 min at 5 C and then added dropwise to a slurry of CuCN (1.3 g, 15 mmol) and KCN (1.6 g, 25 mmol) in water (4 mL), while maintaining the internal temperature between 5-10 C. The mixture was stirred at 10 C for 30 min and then heated at 80 C for 1 h. After cooling, the mixture was extracted with DCM (30 mL x 3). The combined organic layers were washed with brine, dried over Na2S04 and concentrated to afford the title compound. MS: m/z = 230 (M +1). 1H MR (400 MHz, CDC13) delta 8.45-8.53 (m, 1H), 8.33-8.40 (m, 1H), 7.91 (d, 1H, = 8.5 Hz), 4.01 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MITCHELL, Helen; FRALEY, Mark E.; COOKE, Andrew J.; STUMP, Craig A.; BESHORE, Douglas C.; MCCOMAS, Casey C.; SCHIRRIPA, Kathy; ZHANG, Xu-Fang; MCWHERTER, Melody; MERCER, Swati P.; MOORE, Keith; LIU, Chungsing; MAO, Qinghau; (79 pag.)WO2015/143652; (2015); A1;,
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