Related Products of 2901-13-5, These common heterocyclic compound, 2901-13-5, name is Ethyl 2-methyl-2-phenylpropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 2: Synthesis of 2-(4-(chloroacetyl)phenyl)-2-methylpropionic acid ethyl esterIn a 5L reaction flask, add 2,2-dimethylphenylacetic acid ethyl ester (542g, 2.8mol), 2L dichloromethane solution. Stir. Add anhydrous aluminum chloride (600g, 4.5mol), then add dropwise a chloroacetyl chloride (318.6g,2.8mol) in 500mL of methylene chloride mixture. After reacting for a period,detection by TLC finish the reaction was stopped, the organic layer was separated, and the organic layer washed with water, saturated sodium bicarbonate solution , washed with saturated sodium chloride solution, dried and concentrated to give 2-(4-(chloroacetyl)phenyl)-2-methylpropionic acid ethyl ester (660g, 87%).
The synthetic route of 2901-13-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Huawe Medicine Technology Development Co., Ltd.; Xu, Feng; Hu, Dandan; Huang, Hui; Jiang, Yuwei; Zhang, Xiaoqing; (6 pag.)CN104276952; (2016); B;,
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