6279-86-3, These common heterocyclic compound, 6279-86-3, name is Triethyl methanetricarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
10 g 3-Amino-5,5-dimethyl-2-cyclohexen-1-one and 25 g 2-Ethoxycarbonyl-malonic acid diethyl ester are combined and heated for 10 minutes at 210 C. (bath temperature). Thereafter the mixture is cooled to room temperature and triturated with diethylether. The crystalline precipitate is collected by filtration and dried in vacuo.Yield: 9.9 g (49% of theory)Mass spectrometry (ESI+): m/z=280 [M+H]+ Rf-value: 0.45 (silica gel, dichloromethane/methanol 9:1)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6279-86-3.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/46304; (2012); A1;,
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