A new synthetic route of Methyl 2-(4-bromophenyl)-2,2-dimethylacetate

154825-97-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 154825-97-5, name is Methyl 2-(4-bromophenyl)-2,2-dimethylacetate, A new synthetic method of this compound is introduced below.

Example 72C; methyl 2-{4-[(7-amino-5-methyl[l,2,4]triazolo[l,5-alpha]pyrimidin-6-yl)ethynyl]phenyl}-2- methylpropanoate A mixture of Example 72B (17 mg, 0.1 mmol), methyl 2-(4-bromophenyl)-2- methylpropanoate (38 mg, 0.15 mmol), bis(triphenylphosphine)palladium(II) dichloride (3.5 mg, 0.005 mmol), CuI (1 mg, 0.005 mmol), and triethylamine (28 muL, 0.2 mmol) in acetonitrile (500 muL) was heated at 95 0C under nitrogen for 1 h. The resulting mixture was partitioned between ethyl acetate and water. The organic phase was washed with brine, dried over MgSO4, filtered, and concentrated in vacuuo. The residue was purified by flash chromatograph on silica gel (eluting with ethyl acetate) to provide the title compound as a white solid (16 mg, 45% yield). 1H NMR (300 MHz, DMSO-J6) delta 8.44 (s, 3 H), 7.64 (d, J = 8.48 Hz, 2 H), 7.36 (d, J= 8.48 Hz, 2 H), 3.61 (s, 3 H), 2.60 (s, 3 H), 1.52 (s, 6 H). MS (ESI) m/z 350 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ABBOTT LABORATORIES; WO2008/134690; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics