35180-01-9,Some common heterocyclic compound, 35180-01-9, name is Chloromethyl isopropyl carbonate, molecular formula is C5H9ClO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of chloromethyl isopropyl carbonate (5.02 g, 32.77 mmol) in MeCN (20mL) was added Nal (14.74 g, 98.31 mmol). The reaction mixture was stirred at 60 00 for 3 hr. Themixture was then concentrated and the residue was dissolved in DCM (300 mL). The resulting mixture was washed with sat. Na25203 (100 mLx2), and the organic phase was dried and concentrated to give 22.2 (7.90 g, 99% yield). 1H NMR (400 MHz, 0D013): oe5.95 (s, 2H), 4.96 (m, 1H), 1.33 (d, J= 6.4 Hz,6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Chloromethyl isopropyl carbonate, its application will become more common.
Reference:
Patent; UNITY BIOTECHNOLOGY, INC.; BACKES, Bradley; W. VON GELDERN, Thomas; CHEN, Bing; (121 pag.)WO2017/101851; (2017); A1;,
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