35180-01-9, Adding a certain compound to certain chemical reactions, such as: 35180-01-9, name is Chloromethyl isopropyl carbonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35180-01-9.
41.4 g of Tenofovir monohydrate (commercially available or prepared as disclosed in CN1264387A) was added to 164 g of N-methylpyrrolidone at 20~25 C.,Then added under stirring triethylamine 40g, 20 ~ 25 C under stirring for 0.5 hours,Chloromethyl isopropyl carbonate was added 100g, warmed to 55-65 C incubated for 5 hours;Stop heating, cooling to 20 ~ 30 C, adding ethyl acetate 320g, purified water 180g,0 ~ 5 C under stirring after the separation, the lower layer and then 110g of ethyl acetate at 0 ~ 5 C under extraction,Combined ethyl acetate layer, purified water 0 ~ 5 C washed twice, each 320g,30 ~ 35 C concentrated ethyl acetate; cyclohexane was added to the concentrate 150mL,20 ~ 25 C under stirring for 10 hours, filtered, cyclohexane 20mL rinse,Tenofovir disoproxil, white solid.
According to the analysis of related databases, 35180-01-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Pan Xusong; Xiao Ning; Wang Yong; Xiang Zhixiang; Lu Chongyu; Jia Xiaoman; Luo Jie; Zheng Wei; (74 pag.)CN103626803; (2017); B;,
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