Some common heterocyclic compound, 18927-05-4, name is Methyl 3-Methoxyphenylacetate, molecular formula is C10H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 18927-05-4
Methyl bromo(3-methoxyphenyl)acetate; A mixture of 15.7 g (87.1 mmol) of methyl (3-methoxyphenyl)acetate, 16.3 g (91.5 mmol) of Lambda/-bromosuccinimide and a catalytic amount of AIBN in tetrachloromethane (150 ml) was heated under reflux with stirring for 2 h. The cooled reaction solution was filtered and the solvent was removed in vacuo. Yield: 21.8 g (100%) of yellow oil 1H-NMR (DMSOd6): 3.72 (s, 3H), 3.76 (s, 3H), 5.90 (s, 1 H), 6.92-6.97 (m, 1 H), 7.08- 7.13 (m, 2H), 7.28-7.34 (m, 1 H). MS (API-ES,pos) m/z = 261 [M+H]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 18927-05-4, its application will become more common.
Reference:
Patent; ABBOTT GMBH & CO. KG; WO2008/25736; (2008); A1;,
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