In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61644-18-6 as follows. 61644-18-6
Example 6 Isobutyroxymethyl methyl 4-(2′,3′-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate To a stirred mixture of 1,4-dihydro-2,6-dimethyl-4-(2′,3′-dichorophenyl)-5-carboxymethyl-3-pyridinecarboxylic acid (5.11 g, 14 mmol) and sodium bicarbonate (2.39 g, 28 mmol) in DMF (250 ml) under argon atmosphere was added chloromethyl isobutyrate (2.93 g, 21 mmol). The reaction mixture was heated for 80 C. for 18 h. Workup by evaporation of solvent. The crude residue was dissolved in dichloromethane and washed with sodium bicarbonate-solution. The organic layer was dried and evaporated. The residue was chromatographed on silica gel by gradient eluation (dichloromethane to 25% ethyl acetate in dichloromethane). Recrystallization from diisopropylether gave colorless crystals (3.35, 52%), mp. 145 C. 1 H-NMR (CDCl3): 7.30-7.04 (m, 3H); 5.73 (d, J=5.5 Hz, 1H); 5.71 (d, J=5.5 Hz, 1H); 5.68 (s, 1H); 5.47 (s, 1 H); 3.60 (s, 3H); 2.49 (m, 1 H); 2.33 (s, 3H); 2.31 (s, 3H); 1.10 (m, 6H). 13 C-NMR (CDCI3): 175.66; 167.62; 165.77; 147.44; 146.47; 143.78; 132.97; 131.24; 129.81; 128.33; 126.93; 103.99; 102.06; 78.89; 50.86; 38.63; 33.69; 19.83; 19.22; 18.55.
According to the analysis of related databases, 61644-18-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Astra Aktiebolag; US5856346; (1999); A;,
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