61367-07-5, Name is Methyl trans-4-aminocyclohexanecarboxylate hydrochloride, 61367-07-5, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
(1) To a solution of methyl trans-4-aminocyclohexanecarboxylate hydrochloride (1.0 g) obtained in Reference Example 2(1), triethylamine (1.1 ml), 30 % aqueous 3-hydroxypropionic acid solution (1.86 ml) in N,N-dimethylformamide (15 ml) are added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.19 g) and 1-hydroxybenzotriazole (837 mg) under ice-cooling. The mixture is then stirred at room temperature for 20 hours. The reaction solution is concentrated and saturated aqueous sodium hydrogen carbonate solution is poured to the residue, followed by extraction with chloroform. The organic layer is dried over sodium sulfate and evaporated to remove the solvent. The resulting residue is purified by silica gel column chromatography (eluent : ethyl acetate)to give methyl trans-4-[(3-hydroxypropanoyl)amino]cyclohexanecarboxylate (534 mg). APCI-MS M/Z : 230[M+H]+.
Statistics shows that Methyl trans-4-aminocyclohexanecarboxylate hydrochloride is playing an increasingly important role. we look forward to future research findings about 61367-07-5.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; EP1582521; (2005); A1;,
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