455-75-4, A common compound: 455-75-4, name is Ethyl 3-amino-4-fluorobenzoate, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
To a solution of ethyl 3-amiotano-4-fluorobenzoate (547 g, 30 mmol) and pyridine (2 55 mL, 33 mmol) in DCM (150 mL) was added 2,6-diotafluorobenzenesulfonyl chloride (4 45 mL, 33 mmol) The reaction was stirred overnight at rt After 16 h, the reaction mixture was concentrated, triturated with ether, and dried in vacuo to generate 7 87 g (66% yield) of the product of Step A as a white powder ES-LCMS m/z 360 (M+H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-amino-4-fluorobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE LLC; ADJABENG, George; BAUM, Erich; BIFULCO, Neil; DAVIS-WARD, Ronda, G.; DICKERSON, Scott, Howard; DONALDSON, Kelly, Horne; HORNBERGER, Keith; PETROV, Kimberly; RHEAULT, Tara, Renae; SAMMOND, Douglas, McCord; SCHAAF, Gregory, M.; STELLWAGEN, John; UEHLING, David, Edward; WATERSON, Alex, Gregory; WO2010/104899; (2010); A1;,
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