The chemical industry reduces the impact on the environment during synthesis 61367-07-5, name is Methyl trans-4-aminocyclohexanecarboxylate hydrochloride, I believe this compound will play a more active role in future production and life. 61367-07-5
(1) Methyl trans-4-aminocyclohexanecarboxylate hydrochloride (47.5 g) obtained in Reference Example 2(1), bis(2-chloroethyl)ether (34.5 ml), sodium carbonate (77.9 g) and sodium iodide (88 g) are suspended in a mixture of tetrahydrofuran (1400 ml) and N,N-dimethylacetamide (280 ml). The mixture is then heated under reflux for 18 hours. Bis(2-chloroethyl)ether (23 ml) and sodium iodide (22 g) are added to the reaction solution and the mixture is refluxed for additional 6 hours. The reaction solution is concentrated under reduced pressure. The residue is dissolved in ethyl acetate/water and the organic layer is separated. The organic layer is washed with water and saturated brine, dried over sodium sulfate and evaporated to remove the solvent under reduced pressure. The resulting residue is purified by NH-silica gel column chromatography (eluent: ethyl acetate/hexane = 1/30, subsequently by ethyl acetate/hexane = 1/5 followed by 1/3) to give methyl trans-4-morpholin-4-ylcyclohexane-carboxylate (53.9 g). APCI-MS M/Z:228[M+H]+.
The chemical industry reduces the impact on the environment during synthesis 61367-07-5. I believe this compound will play a more active role in future production and life.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; EP1582521; (2005); A1;,
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